Lipid Peroxidation and Lipid Profile in Type II Diabetes Mellitus

The study was designed to find out the relation between lipid peroxidation, lipoprotein levels to severity and complication of diabetes mellitus. Degree of lipid peroxidation was measured in terms of malondialdehyde (MDA) along with antioxidants, lipid profile and blood glucose in diabetes mellitus. Total 100 human subjects, out of which 50 healthy individuals of age group (50-70years) were taken as control & 50 elderly diabetic subjects of age group (50-70years) were taken as cases. There was significant increase in the lipid profile except HDL cholesterol, which is decreased, Also significant decrease in antioxidant enzymes such as Reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase except catalase was seen as compared to the control subjects. Other findings observed was that the level of lipid peroxide (MDA) increased as per the increase in concentration of blood glucose. Our findings indicate that the increase in the lipid peroxidation product MDA and decline in glutathione-dependent antioxidant defences may appear early in non insulin dependent type 2diabetes mellitus patients.